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Stuart A. Tobet, Ph.D.

Professor of Biomedical Sciences, Colorado State University

Dr. Stuart Tobet - Send email to Stuart.Tobet@ColoState.EDU

Stuart A. Tobet, Ph.D., SCOR Co-PI & Co-Director & PI of Project 2, is a developmental neurobiologist with backgrounds in neuroendocrinology, neurochemistry, immunochemistry, and neuroanatomy. Since 1975 he has been involved with studies of the biological basis for sex differences in brain structure and function, and the developmental mechanisms that drive brain sexual differentiation in animal models, using rat, ferret, and mouse models. He was the first to describe a sex difference in the preoptic area of a non-rodent species (ferrets). His early behavioral studies led to the one of the few proposals of a mechanism to reconcile the differential effectiveness of estrogen in primate versus rodent species for brain sexual differentiation. His current studies focus on molecular mechanisms by which gonadal steroids influence fundamental developmental processes (neurogenesis, migration, specification, and death) to produce sex differences in brain organization.

Dr. Tobet received his S.M. (1982) and Ph.D. (1985) from the Massachusetts Institute of Technology and then took a postdoctoral position at the Shriver Center for Mental Retardation Research in Waltham, as part of the Harvard Medical School/MGH Department of Neurology. In 1989, he became an Assistant Professor at the Shriver Center where he also directed the Image Analysis Facilities. In 2000, the University of Massachusetts Medical School took over the Shriver Center rendering Dr. Tobet an Associate Professor in Physiology in addition to his position at the Center. In 2003, Dr. Tobet took a position as Associate Professor of Biomedical Sciences at Colorado State University in Fort Collins, CO and became Full Professor in July 2006. He became one of the original core faculty for the School of Biomedical Engineering Program at CSU when it was established in 2007. In the summer of 2010 he was elected the Director of the School of Biomedical Engineering.

At CSU Dr. Tobet started a number of interdisciplinary projects that bring together faculty in his home department of Biomedical Sciences with those in electrical and computer engineering, chemical and biological engineering, chemistry, mathematics, and computer science. These projects share the common goal of building ways to directly visualize chemical signaling in live tissue. Levels of resolution range from pixel level laser-based microscopy, to electrode driven electrochemistry, to microfluidic-based spatial resolved sampling. These new tools will provide the potential for a level of analysis that will transform our understanding of brain development and function.

Publications by Dr. Tobet