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Bill Lasley, Ph.D.

  • Professor of Reproductive Medicine and Obstetrics/Gynecology, Schools of Veterinary and Human Medicine
  • Associate Director of the Center for Health and the Environment
  • Director of the Endocrine Core at the California National Center for Primate Research
Dr. Bill L. Lasley - Send email to bllasley@ucdavis.edu

Dr. Lasley’s research is directed to gaining a deeper understanding of the role of hormones in women’s health.  He serves as Chairperson of the Laboratory Liaison Committee and a member of the SWAN Repository Organization for the Study of Women’s Health Across the Nation (SWAN) with the responsibility (along with the Core Laboratory Leader, Dr. McConnell) to insure that all laboratory methods and data are of the highest quality for all samples. HE is also a permanent member of the SWAN Executive (EC) and Steering (SC) Committees as well as the Animal Core Leader in John Morrison’s Program Project that is using the nonhuman primate animal model to investigate the role of estrogen action on the preserving brain structure/function in the aging female primate. He is a participate as a collaborator in studies relating to embryonic determinants of adult health (EDAH) and lead studies in his own laboratory on reproductive toxicology.  His research background has been in clinically-relevant in studies relating to human reproduction/development, reproductive epidemiology and reproductive toxicology, a career that has lasted for more than 35 years. His laboratory group has been responsible for the development, validation and early application of many of the methods for evaluating reproduction and development in population–based studies. Over 300 peer-reviewed reports that deal with women’s reproductive health have been published by his group over the past three decades. Most recently these have dealt with the role of the adrenal in women’s healthy aging.

Representative Publications:

Crawford S, Santoro N, Laughlin GA, Sowers MF, McConnell D, Sutton-Tyrrell K, Weiss G, Vuga M, Randolph J, Lasley BL. Circulating Dehydroepiandrosterone Sulfate Concentrations during the Menopausal Transition. J Clin Endocrinol Metab 94(8):2945-51, 2009.

Gold EB, Lasley BL, Crawford SL, McConnell D, Joffe H, Greendale GA. Relation of daily hormone patterns to vasomotor symptoms in a diverse group of mid-age women. Repro Sci 14(8):786-797, 2007.

Chen J, Sowers MF, Moran FM, McConnell DS, Gee NA, Greendale GA, Whitehead C, Kasim-Karakas S, Lasley BL.  Circulating bioactive androgens in midlife women. J. Clin Endocrinol Metab 91(11): 4387-94, 2006.

Lasley BL, Santoro N, Gold EB, Sowers MF, Crawford S, Weiss G, McConnell DS, Randolph J. The relationship of circulating DHEAS, testosterone and estradiol to stages of the menopausal transition and ethnicity.  J. Clin Endocrinol Metab  87:3760-3767, 2002.

Randolph JF, Sowers MF, Gold EB, Mohr B, Luborsky J, Santoro N, McConnell D, Finkelstein F, Matthews K, Korenman S, Sternfeld BX, Lasley BL.  Reproductive hormones in the early menopausal transition: Ethnicity, body size and menopausal status. J. Clin Endocrinol Metab  88:1516-1522, 2003.

Lasley BL, Crawford SL, Laughlin GA, Santoro N, McConnell DS, Crandall C, Greendale GA, Polotsky AJ, Vuga M. Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transition. Menopause 18(5): 494-498, 2011

Lasley BL, Stanczyk FX, Gee NA, Chen J, El Khoudary, Crawford S, McConnell DS.  Androstenediol Complements Estradiol During the Menopausal Transition. Menopause, In press, on line.

McConnell DS, Santoro N, Randolf JR, Stanczyk FZ, Lasley BL. Menopausal Transition Stage-Specific Changes in Circulating Adrenal Androgens, In press, on line.

Fan X, Kreig S, Hwang JY, Dhal S, Kuo CJ, Lasley BL, Brenner Rm, Nayak NR. Dynamic regulation of Wnt7a in the primate endomtrium: Implications for regeneration and secretory transformation, Endocrinol 153(3), 2012.

Publications by Dr. Lasley