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Jane Epstein, M.D.

  • Director, Neuropsychiatry Education and Training,
    Department of Psychiatry,
    Brigham and Women’s Hospital
  • Lecturer,
    Department of Psychiatry, Harvard Medical School
Dr. Jane Epstein - Send email to jiepstein@partners.org

Jane Epstein, M.D. is an investigator in the Functional Neuroimaging Laboratory at the Brigham and Women’s Hospital.  Following her residency training in psychiatry at the New York Presbyterian Hospital/Payne Whitney Clinic, Dr. Epstein completed fellowships in Schizophrenia Research and Behavioral Neurology/Geropsychiatry at the Mt. Sinai School of Medicine and Beth Israel Medical Center in New York City.  Her clinical focus is on cognitive, affective, perceptual and behavioral manifestations of neurologic disorders; her research focus is on the functional neuroanatomy of primary psychiatric disorders.  She is particularly interested in the neural substrates of conscious and nonconscious motivational/affective processing in normal and psychiatric populations.

Representative Publications:

Butler T, Weisholtz D, Isenberg N, Harding E, Epstein J, Stern E, Silbersweig DA.  Neuroimaging of frontal-limbic dysfunction in schizophrenia and epilepsy-related psychosis: Toward a convergent neurobiology.  Epilepsy & Behavior, in press.

Epstein J, Perez D, Ervin K, Pan H, Kocsis JH, Butler T, Stern E, Silbersweig DA.  Failure to segregate emotional processing from cognitive and sensorimotor processing in major depression.  Psychiatry Research: Neuroimaging, 193: 144-150, 2011.

Pan H, Epstein J, Stern E, Silbersweig DA.  New and Emerging Techniques for Mapping Brain Circuitry.  Brain Research Reviews, 67(1-2): 226-251, 2011.

Chen H, Epstein J, Stern E.  Neuroplasticity after acquired brain injury:  evidence from functional neuroimaging.  Physical Medicine and Rehabilitation, Suppl 2, S306-S312, 2010.

Cunningham-Bussel A, Root J, Butler T, Tuescher O, Pan H, Epstein J, Weisholtz D, Pavony M, Silverman M, Goldstein M, Altemus M, Cloitre M, LeDoux J, McEwen B, Stern E, Silbersweig D.  Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli.  Psychoneuroendocrinology, 34(5): 694-704, 2009.

Protopopescu X, Tuescher O,  Pan H, Epstein J, Root J, Chang L, Altemus M, Polanecsky M, McEwen B, Stern E, Silbersweig D.  Toward a functional neuroanatomy of premenstrual dysphoric disorder.  Journal of Affective Disorders, 108(1-2): 87-94, 2008.

Butler T, Pan H, Tuescher O, Engelien A, Goldstein M, Epstein J, Weisholtz D, Root JC, Protopopescu X, Cunningham-Bussell AC, Chang L, Xie X, Qiang C, Phelps EA, Ledoux JE, Stern E, Silbersweig DA.  Human fear-related motor neurocircuity.  Neuroscience, 150(1):  1-7, 2007.

Silbersweig D, Clarkin JF, Goldstein M, Kernberg OF, Tuescher O, Levy KN, Brendel G, Pan H, Beutel M, Pavony MT, Epstein J, Lenzenweger MF, Thomas K, Posner MI, Stern E.  Failure of fronto-limbic inhibitory function in the context of negative emotion in borderline personality disorder.  American J. Psych., 164: 1832-1841, 2007.

Epstein J, Pan H, Kocsis J, Yang Y, Butler T, Chusid J, Hochberg H, Murrough J, Strohmayer E, Stern E, Silbersweig D.  Lack of ventral striatal response to positive stimuli in depressed versus normal subjects.  American J. Psych., 163: 1784-1790, 2006.

Butler T, Pan H, Epstein J, Protopopescu X, Tuescher O, Goldstein, M, Cloitre M, Yang Y, Phelps E, Gorman J, Ledoux J, Silbersweig D, Stern E.  Fear-related activity in subgenual anterior cingulate differs between men and women.  NeuroReport, 16(11): 1233-1236, 2005.

Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien W, Epstein J, Yang Y, Gorman J, LeDoux J, Silbersweig DA, Stern E. Differential time-courses and specificity of amygdala activation in PTSD subjects and normal controls. Biol. Psych., 57(5): 464-73, 2005.

Epstein J, Stern E & Silbersweig D.  Mesolimbic activity associated with psychosis in schizophrenia:  Symptom-specific PET studies, Annals of the NY Acad. of Sci., 877:  562-574, 1999.

Publications by Dr. Epstein